RapamycinFungusV1, Main, Exploration, bibRecord, 000329

Hyperactive TORC1 sensitizes yeast cells to endoplasmic reticulum stress by compromising cell wall integrity.

Identifieur interne : 000329 ( Main/Exploration ); précédent : 000328; suivant : 000330

Hyperactive TORC1 sensitizes yeast cells to endoplasmic reticulum stress by compromising cell wall integrity.

Auteurs : Khadija Ahmed [Canada] ; David E. Carter [Canada] ; Patrick Lajoie [Canada]

Source :

FEBS letters [ 1873-3468 ] ; 2019.

RBID : pubmed:31144305

Descripteurs français

English descriptors

KwdEn :
- Caspofungin (pharmacology), Cell Wall (metabolism), Endoplasmic Reticulum (metabolism), Endoplasmic Reticulum Stress (drug effects), Gene Expression Profiling (MeSH), Gene Expression Regulation, Fungal (drug effects), Saccharomyces cerevisiae (drug effects), Saccharomyces cerevisiae (genetics), Saccharomyces cerevisiae (metabolism), Saccharomyces cerevisiae Proteins (genetics), Saccharomyces cerevisiae Proteins (metabolism), Transcription Factors (genetics), Transcription Factors (metabolism), Unfolded Protein Response (drug effects).
MESH :
- chemical , genetics : Saccharomyces cerevisiae Proteins, Transcription Factors.
- chemical , metabolism : Saccharomyces cerevisiae Proteins, Transcription Factors.
- chemical , pharmacology : Caspofungin.
- drug effects : Endoplasmic Reticulum Stress, Gene Expression Regulation, Fungal, Saccharomyces cerevisiae, Unfolded Protein Response.
- genetics : Saccharomyces cerevisiae.
- metabolism : Cell Wall, Endoplasmic Reticulum, Saccharomyces cerevisiae.
- Gene Expression Profiling.

Abstract

Accumulation of misfolded proteins in the endoplasmic reticulum (ER) activates the unfolded protein response (UPR). Here, we investigated how the target of rapamycin complex 1 (TORC1) signaling cascade acts in parallel with the UPR to regulate ER stress sensitivity. Using Saccharomyces cerevisiae, we found that TORC1 signaling is attenuated during ER stress and constitutive activation of TORC1 increases sensitivity to ER stressors independently of the UPR. Transcriptome analysis revealed that TORC1 hyperactivation results in cell wall remodelling. Conversely, hyperactive TORC1 sensitizes cells to cell wall stressors, including the antifungal caspofungin. Elucidating the crosstalk between the UPR, cell wall integrity, and TORC1 signaling may uncover new paradigms through which the response to protein misfolding is regulated.

DOI: 10.1002/1873-3468.13463
PubMed: 31144305

Affiliations:

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Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Caspofungin (pharmacology)</term>
<term>Cell Wall (metabolism)</term>
<term>Endoplasmic Reticulum (metabolism)</term>
<term>Endoplasmic Reticulum Stress (drug effects)</term>
<term>Gene Expression Profiling (MeSH)</term>
<term>Gene Expression Regulation, Fungal (drug effects)</term>
<term>Saccharomyces cerevisiae (drug effects)</term>
<term>Saccharomyces cerevisiae (genetics)</term>
<term>Saccharomyces cerevisiae (metabolism)</term>
<term>Saccharomyces cerevisiae Proteins (genetics)</term>
<term>Saccharomyces cerevisiae Proteins (metabolism)</term>
<term>Transcription Factors (genetics)</term>
<term>Transcription Factors (metabolism)</term>
<term>Unfolded Protein Response (drug effects)</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Analyse de profil d'expression de gènes (MeSH)</term>
<term>Caspofungine (pharmacologie)</term>
<term>Facteurs de transcription (génétique)</term>
<term>Facteurs de transcription (métabolisme)</term>
<term>Paroi cellulaire (métabolisme)</term>
<term>Protéines de Saccharomyces cerevisiae (génétique)</term>
<term>Protéines de Saccharomyces cerevisiae (métabolisme)</term>
<term>Régulation de l'expression des gènes fongiques (effets des médicaments et des substances chimiques)</term>
<term>Réponse aux protéines mal repliées (effets des médicaments et des substances chimiques)</term>
<term>Réticulum endoplasmique (métabolisme)</term>
<term>Saccharomyces cerevisiae (effets des médicaments et des substances chimiques)</term>
<term>Saccharomyces cerevisiae (génétique)</term>
<term>Saccharomyces cerevisiae (métabolisme)</term>
<term>Stress du réticulum endoplasmique (effets des médicaments et des substances chimiques)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Saccharomyces cerevisiae Proteins</term>
<term>Transcription Factors</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Saccharomyces cerevisiae Proteins</term>
<term>Transcription Factors</term>
</keywords>
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</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Endoplasmic Reticulum Stress</term>
<term>Gene Expression Regulation, Fungal</term>
<term>Saccharomyces cerevisiae</term>
<term>Unfolded Protein Response</term>
</keywords>
<keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Régulation de l'expression des gènes fongiques</term>
<term>Réponse aux protéines mal repliées</term>
<term>Saccharomyces cerevisiae</term>
<term>Stress du réticulum endoplasmique</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Saccharomyces cerevisiae</term>
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<term>Protéines de Saccharomyces cerevisiae</term>
<term>Saccharomyces cerevisiae</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Cell Wall</term>
<term>Endoplasmic Reticulum</term>
<term>Saccharomyces cerevisiae</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Facteurs de transcription</term>
<term>Paroi cellulaire</term>
<term>Protéines de Saccharomyces cerevisiae</term>
<term>Réticulum endoplasmique</term>
<term>Saccharomyces cerevisiae</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Caspofungine</term>
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<front><div type="abstract" xml:lang="en">Accumulation of misfolded proteins in the endoplasmic reticulum (ER) activates the unfolded protein response (UPR). Here, we investigated how the target of rapamycin complex 1 (TORC1) signaling cascade acts in parallel with the UPR to regulate ER stress sensitivity. Using Saccharomyces cerevisiae, we found that TORC1 signaling is attenuated during ER stress and constitutive activation of TORC1 increases sensitivity to ER stressors independently of the UPR. Transcriptome analysis revealed that TORC1 hyperactivation results in cell wall remodelling. Conversely, hyperactive TORC1 sensitizes cells to cell wall stressors, including the antifungal caspofungin. Elucidating the crosstalk between the UPR, cell wall integrity, and TORC1 signaling may uncover new paradigms through which the response to protein misfolding is regulated.</div>
</front>
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<Month>06</Month>
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<Abstract><AbstractText>Accumulation of misfolded proteins in the endoplasmic reticulum (ER) activates the unfolded protein response (UPR). Here, we investigated how the target of rapamycin complex 1 (TORC1) signaling cascade acts in parallel with the UPR to regulate ER stress sensitivity. Using Saccharomyces cerevisiae, we found that TORC1 signaling is attenuated during ER stress and constitutive activation of TORC1 increases sensitivity to ER stressors independently of the UPR. Transcriptome analysis revealed that TORC1 hyperactivation results in cell wall remodelling. Conversely, hyperactive TORC1 sensitizes cells to cell wall stressors, including the antifungal caspofungin. Elucidating the crosstalk between the UPR, cell wall integrity, and TORC1 signaling may uncover new paradigms through which the response to protein misfolding is regulated.</AbstractText>
<CopyrightInformation>© 2019 Federation of European Biochemical Societies.</CopyrightInformation>
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<Language>eng</Language>
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<Agency>Canada Foundation for Innovation</Agency>
<Country>International</Country>
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<Agency>Natural Sciences and Engineering Research Council of Canada</Agency>
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	Serveur d'exploration sur la rapamycine et les champignons
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Serveur d'exploration sur la rapamycine et les champignons

Hyperactive TORC1 sensitizes yeast cells to endoplasmic reticulum stress by compromising cell wall integrity.

Hyperactive TORC1 sensitizes yeast cells to endoplasmic reticulum stress by compromising cell wall integrity.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

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